The roles of a flagellar HSP40 ensuring rhythmic beating

Rhythmicity, recurrence, and recovery of flagellar beating.

The eukaryotic flagellum beats with apparently unfailing periodicity, yet responds rapidly to stimuli. Like the human heartbeat, flagellar oscillations are now known to be noisy. Using the alga C. reinhardtii, we explore three aspects of nonuniform flagellar beating. We report the existence of rhythmicity, waveform noise peaking at transitions between power and recovery strokes, and fluctuation...

Targeted dynein inhibition generates flagellar beating

Flagellar and ciliary beating in trypanosome motility.

The single flagellum of Leishmania and Trypanosoma parasites is becoming an increasingly attractive model for the analysis of flagellar function-driven largely by the abundance of genomic and proteomic information available for the organelle, the genetic manipulability of the organisms and the importance of motility for the parasite lifecycle. However, as yet, there is a paucity of published da...

Nonlinear amplitude dynamics in flagellar beating

The physical basis of flagellar and ciliary beating is a major problem in biology which is still far from completely understood. The fundamental cytoskeleton structure of cilia and flagella is the axoneme, a cylindrical array of microtubule doublets connected by passive cross-linkers and dynein motor proteins. The complex interplay of these elements leads to the generation of self-organized ben...

Swimming Controlled by Ciliary or Flagellar Beating

It has been k membrane po ity of ciliated potential of c means by mec ture stimuli ( mechanical st plasma memb FIGURE 1. Th channels (40) vating voltage iary/flagellar m an increase of in turn initiate movement. In ciliary Ca2+ co K+ channels. T brane potentia ated forward conductance tants and pher tivation of v characteristic ing rapidly ba (90). So far, th lar identificati Paramecium e chann...